Starting an application shows a popup with a question whether to start the file or not as the source oft the file is Internet.
The file itself is located on a server defined as safe place within the organization. So there is not the problem.
Copy the file to a FAT32 formated memory stick an back to strip some information from the file
Change the security Level by using the following command
C:\> icacls <Filenlocation and name.exe> /Setintegritylevel (OI)L